The duration varies according to the treated area and the individual degradation capacity of each patient. Generally speaking: for lips, 6 to 12 months; for nasolabial folds, 9 to 18 months; for dark circles, 8 to 12 months; for cheekbones, approximately one year; and with highly cross-linked products such as Voluma, up to 24 months. Factors such as particle size, molecular weight, concentration and level of cross-linking of the product directly influence the durability of the treatment.